Effect of Allogeneic Platelet Lysate and Cyanoacrylate Glue on the Fibrovascularization of the Medpor Implant

Because of limited autogenous tissue sources, donor site morbidity, and difficulty of shaping the autologous tissue, surgeons often need to use alloplastic frameworks in reconstruction of three dimensional tissue defects. Medpor (Porex Surgical, College Park, CA, USA) a synthetic porous polyethylene (PP) implant is widely used in plastic surgery for three-dimensional reconstruction of the lost or highly deformed tissues. One of the main factors of PP implant exposure is delayed fibrovascular ingrowth. In the present study, we investigated the effect allogeneic platelet lysate (PL) and Glubran2- (2-octyl cyanoacrylate)(CTG) on the fibrovascularization of the PP implant. Twenty 10 weeks-old adult female Wistar rats were divided into 4 groups equally, according to the different surgical techniques and implanted materials used. Group 1 was only implanted with PP, Group 2 was implanted with PP with CTG, Group 3 was implanted with PP with PL, and Group 4 was implanted with PP with CTG and PL. All of the implants in each group were histologically assessed at postoperative week 2. Determination of the collagen density in the tissues, inflammation, necrosis and vascularization status was assessed semi quantitatively. At the gross examination of the implants, we saw that all the implants in the PL groups (Groups 3 and 4) were totally covered with the soft tissue. On the other hand, some implants in the control and CTG only groups (Groups 1 and 2) showed partial external soft tissue coverage. A denser collagen structure, low inflammation and necrosis were found in PL groups.PL can be easily and rapidly produced and used in bio integration of PP safely.