Purpose: To determine the efficacy of fibrin glue in latissimus donor sites to reduce seroma.

Background: Donor site seroma continues to be a significant problem with latissimus flap reconstruction, with a complication rate as high as 79%. Various methods of prevention have been described including endoscopically assisted harvest, compression bandages, avoidance of electrocautery, and quilting sutures. Fibrin sealant has been successfully used to decrease seroma in rat latissimus donor sites. Fibrin sealant has also reduced the duration and amount of fluid drainage after axillary dissection in humans.

Materials and Methods: Prospective study of consecutive latissimus flap patients at one institution receive fibrin glue in their donor site prior to closure. Controls consist of 20 consecutive latissimus patients prior to start of study who received no fibrin glue.

Results: 1 out of 9 treated patients developed a seroma (11%) vs 7 out of 20 control patients (35%). Drains were present for a mean of 5.8 days in treated patients and 8.8 days in controls.

Conclusion: Fibrin glue appears to decrease seroma in latissimus donor sites. We are continuing to add patients to the study to increase statistical power