Although commonly used as a therapeutic modality, skin graft physiology remains poorly understood. Using recent advances in murine models, the present study was undertaken to investigate the survival of the vasculature donor cells and in-growth of vasculature recipient cells within full thickness skin grafts. Full thickness skin grafts were exchanged between immunohistocompatible C57BL6 control mice and transgenic enhanced green fluorescent protein (eGFP) expressing C57BL6 mice. These grafts were then harvested with underlying tissue over a series of time points from 3 days to 2 months. Using fluorescent labeling of endothelial cells, the survival of both donor and recipient endothelial cells were analyzed. Full thickness skin grafts exchanged between the two mice survived for up to two months. The vasculature demonstrates fluorescent staining indicating both donor and recipient origin. Vasculature of recipient origin presents later in time during the graft incorporation. Using advances in transgenic mice, we have developed a potentially powerful model system for studying donor and recipient physiology of grafting. The use of this model has demonstrated at the cellular level that revascularization of full thickness skin grafts is dependent both upon the reanastomosis of preexisting vessels, inosculation, and the in-growth of new vessels.