Re-epithelialization of split-thickness skin graft donor sites continues to pose a challenge to plastic surgeons. Rakel et al. in an extensive donor site dressing review concluded that moist healing environment provided optimal healing times. The purpose of this study is to compare re-epithelialization rates of Acticoat^TM and Allevyn^TM to a known standard Xeroform^TM. In a population of rats, three split-thickness skin grafts were taken from the back of each male rat (n=17). The three wounds were covered with Acticoat^TM, Allevyn^TM, and Xeroform^TM on each rat. On post-operative days three and six the Acticoat^TM and Allevyn^TM dressings were removed, new dressing placed, and digital photographs of the wounds taken. The photographs were shown to three experienced plastic surgeons, and the degree of wound healing was evaluated for each rat at each donor site. Epithelialization was the measured end-point. The Xeroform^TM dressed wounds epithelialized more rapidly. Cost comparisons were also included in this study.