Introduction: Plastic surgeons commonly encounter patients who are anticoagulated for various conditions. Many of these patients also suffer from burn injuries or chronic lower extremity wounds that require autografting. The standard of perioperative care for anticoagulated patients involves discontinuation of warfarin 4-5 days before surgery, and resumption of warfarin postoperatively +/- low molecular weight heparin. This transition may increase risk of perioperative thrombotic complications and cost. Methods: A retrospective study of 15 patients (8 females / 7 males) who underwent autografting of extremity burns (<2% TBSA) or chronic wounds (<1% TBSA) while remaining on warfarin (INR 2-3) was performed. All burns/wounds were tangentially excised under tourniquet control. Hemostasis was obtained utilizing electrocautery, thrombin spray and pressure dressings. Grafts were affixed with fibrin sealant, and donor skin was harvested from the ipsilateral thigh. Results: There were no peri/post-operative bleeding complications. No graft loss was noted. Conclusion: Based on this limited number of patients, it may be safe to continue warfarin therapy in patients requiring autografting for minor burn and chronic wounds of the extremities. Further study is required to demonstrate the safety of this approach statistically.