Purpose: Although several studies have analyzed risk factors for tissue expander removal prior to permanent implant placement in breast reconstruction, outcomes following explantation for infection are unknown. Methods/Materials: From a prospectively maintained database covering a 10-year period, 39 such patients were identified. A retrospective chart review was performed, noting patient characteristics which might affect outcome of secondary reconstruction. Reasons for reconstruction vs. no reconstruction were evaluated with chart reviews and discussions with patients and surgical attendings. Fisher's Exact Test was performed to ascertain if any characteristics were associated with secondary reconstructive outcome. Results: Twelve patients (30.8%) had prior radiotherapy. Nine (23%) underwent re-expansion, three had a latissimus dorsi flap and expander, and one received a free transverse rectus abdominis flap. Recurrent infection occurred in one re-expanded patient. Two patients developed late contractures. All other reconstructions were successful. Twenty-six patients (66.7%) did not undergo reconstruction, commonly due to patient preference, cancer progression, and/or radiotherapy. Conclusions: After removal of an infected expander, most patients who are interested and remain good candidates can be reconstructed. Re-expansion was successful in patients without prior radiotherapy. Secondary reconstruction with autologous tissue is appropriate when there is a history of radiotherapy.