Introduction: Wound care management in pediatric patients typically consists of daily dressing changes. Negative pressure wound therapy provides an alternative therapy system that requires less frequent changes in the adult population. We reviewed the usage of negative pressure wound therapy in our childrens hospital. Methods: Pediatric patients receiving negative pressure wound therapy from January 2005 to April 2006 were identified. After IRB approval a chart review of all 39 patients was performed for demographics, wound location, duration of therapy, complications, location of therapy, and wound closure. Results: The mean age of the patients was 8.5±5.7 with 1% of patients under 1 year of age and 13% less than 1 month of age. The wounds were divided into 2 groups trunk (25) and extremity (14). The average number of days the negative pressure wound therapy was used on each patient was 20.6±9.1. Wound closure was completed in all patients with 54% closing by secondary intention. Discussion: Negative pressure wound therapy provides a safe effective alternative to traditional wound care in the pediatric population including infants under 1 year of age. In our study there were no complications and 54% of the patients went on to secondary closure without requiring further surgery.