Backround The formation of seroma is one of the most frequent complications following abdominoplasty. The effect of intraoperative fibrin sealant on the formation of seroma was investigated in patients who had an abdominoplasty. The relevance of slow versus accelerated fibrin polymerization was determined. Material and Methods Two different thrombin concentrations (4 IE vs 500 IE thrombin/ml) of the fibrin sealant were used in two groups of 40 patients. The control group consisted of 40 patients with abdominoplasties without fibrin glue adhesion. Results Patients in the group with the slow reacting fibrin sealant (4 IE) had a significantly lower rate of seroma formation when compared to the high concentration fibrin group and the control (p< 0.025 and p< 0.001, respectively). In addition, the amount of postoperative drainage was significantly lower in the low-dose group (p<0.000). Patients with seroma had a significantly higher weight of resected tissue (p<0.003). Smoking was found to be a significant risk factor for the development of seroma (p< 0.03). The amount of postoperative drainage, age and body-mass-index had no significant impact on the prevalence of complications. Conclusion The use of slow reacting, low-dose fibrin glue demonstrated a protective effect against the formation of seroma following abdominoplasty. The amount of postoperative drainage was significantly lower.