Xeomin Vs. Botox a Side-By-Side Comparison in the Same Patients

Marketing disinformation has confused physicians about the comparative safety and efficacy of Botox and Xeomin.   Comparative studies to date were in different patients. Variations of onset and duration are significant in different patients using the same product.  Thus comparing the two products is not reliable.  In this study, Xeomin was injected in one side of the forehead and Botox was injected on the other side in the same patients.  By eliminating the patient variable, a true comparison was possible.  Patients were videotaped for four months to compare onset and duration.  Though onset and duration varied among different patients, onset and duration in each individual patient was identical.

100 units of Xeomin were diluted in 10 cc of saline.  100 units of Botox were diluted in 10 cc of saline.  Thus a 1cc syringe of Botox contained 10 units, and 1cc syringe of Xeomin contained 10 units.

Four vertical lines were evenly spaced left and right of the midline as shown.  2 units of neurotoxin in .2cc of saline was injected along each line vertically for a total of eight units of Xeomin on the right and eight units Botox on the left.  A total of 16 units.  The midline space was twice the width of the spacing between lines laterally to avoid crossover.

In ten patients, paralysis was complete and symmetrical at three to 5 days.  Weak muscle function resumed at two to three months with complete function at three to four months.  Though different individuals varied in onset and duration, each patient exhibited onset and recovery identically on each side.

 Xeomin and Botox are equal unit for unit as would be expected by their similar composition.

Pre-injection markings Xeomin R, Botox left